After discovering that a patient's family might have been abusive, Dr. Choi and April contemplate calling child services. Dr. Manning and Dr. Halstead struggle to see eye to eye in guiding a family who is dealing with their premature baby. Dr. Rhodes is persuaded into preforming a risky surgery on Dr. Bekker's mentor. Meanwhile, Dr. Reese joins Dr. Charles on a visit to the Cook County jail.
After witnessing a drive-by shooting and hitting her head, Dr. Manning struggles with the aftermath of a head injury. Complicating matters, she and Dr. Halstead deal with a teenage patient and her overbearing older husband, who might not be looking out for his young wife's best interests. Dr. Rhodes finds himself in a unique situation when he learns alarming information about the woman he went on a date with. Maggie is surprised to discover some unexpected things about the man she has been seeing. Dr. Charles is frustrated when Dr. Reese disobeys his orders and puts herself at risk.
An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.